The hepatocurative effects of Cynara scolymus L. leaf extract on carbon tetrachloride-induced oxidative stress and hepatic injury in rats

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The hepatocurative effects of Cynara scolymus L. leaf extract on carbon tetrachloride-induced oxidative stress and hepatic injury in rats

Cynara scolymus is a pharmacologically important medicinal plant containing phenolic acids and flavonoids. Experimental studies indicate antioxidant and hepatoprotective effects of C. scolymus but there have been no studies about therapeutic effects of liver diseases yet. In the present study, hepatocurative effects of C. scolymus leaf extract on carbon tetrachloride (CCl4)-induced oxidative st...

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The Effects of Cynara scolymus L. Leaf and Cichorium intybus L. Root Extracts on Carbon Tetrachloride Induced Liver Toxicity in Rats

Background: Cynara scolymus and Cichorium intybus are popular herbal remedy in folk medicine for liver disorders. Although many experimental studies carried out, scientifically reliable data needed to verify minimum effective dosage and efficacy of these medicinal plants. Objective: In present investigation, the effects of C. scolymus leaf and C. intybus root extracts at different doses were t...

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the effects of cynara scolymus l. leaf and cichorium intybus l. root extracts on carbon tetrachloride induced liver toxicity in rats

background: cynara scolymus and cichorium intybus are popular herbal remedy in folk medicine for liver disorders. although many experimental studies carried out, scientifically reliable data needed to verify minimum effective dosage and efficacy of these medicinal plants. objective: in present investigation, the effects of c. scolymus leaf and c. intybus root extracts at different doses were te...

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Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

This study investigated the protective effects of melatonin and folic acid against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Oxidative stress, liver function, liver histopathology and serum lipid levels were evaluated. The levels of protein kinase B (Akt1), interferon gamma (IFN-γ), programmed cell death-receptor (Fas) and Tumor necrosis factor-alpha (TNF-α) mRNA expression we...

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ژورنال

عنوان ژورنال: SpringerPlus

سال: 2016

ISSN: 2193-1801

DOI: 10.1186/s40064-016-1894-1